2. Metabolic Enzyme/Protease
  3. Drug Metabolite Phosphatase
  4. 6-Hydroxybenzbromarone

6-Hydroxybenzbromarone is the major metabolite of Benzbromarone with a longer half-life and greater pharmacological potency than the parent compound. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor with an IC50 value of 21.5 μM. 6-Hydroxybenzbromarone is an anti-angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic sprouting.

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6-Hydroxybenzbromarone Chemical Structure

6-Hydroxybenzbromarone Chemical Structure

CAS No. : 152831-00-0

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Based on 1 publication(s) in Google Scholar

6-Hydroxybenzbromarone Related Antibodies

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  • Purity & Documentation

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Description

6-Hydroxybenzbromarone is the major metabolite of Benzbromarone with a longer half-life and greater pharmacological potency than the parent compound. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor with an IC50 value of 21.5 μM. 6-Hydroxybenzbromarone is an anti-angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic sprouting[1].

IC50 & Target

IC50: 21.5 μM (EYA3); metabolite[1]
In Vitro

6-Hydroxybenzbromarone (7.5 μM; 72 hours) shows over 50% reduction in cell proliferation. Meanwhile, treatment with BBR and BZ also reduces cell viability, but none of the other compounds tested has a negative impact on cell viability or proliferation[1].
6-Hydroxybenzbromarone (7.5 μM; 1-20 hours) has inhibitory affects EC migration tubulogenesis of HUVECs. However, the effect of 6OH-BBR on tube formation is attenuated in the presence of high concentrations of fetal bovine serum (FBS), likely reflecting non-specific protein binding[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6-Hydroxybenzbromarone Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HUVEC cells
Concentration: 7.5 μM
Incubation Time: 72 hours 
Result: Inhibited HUVEC cells proliferation.
Molecular Weight

440.08

Formula

C17H12Br2O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC(Br)=C(O)C(Br)=C1)C2=C(CC)OC3=CC(O)=CC=C23
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (227.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2723 mL 11.3616 mL 22.7231 mL
5 mM 0.4545 mL 2.2723 mL 4.5446 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2723 mL 11.3616 mL 22.7231 mL 56.8079 mL
5 mM 0.4545 mL 2.2723 mL 4.5446 mL 11.3616 mL
10 mM 0.2272 mL 1.1362 mL 2.2723 mL 5.6808 mL
15 mM 0.1515 mL 0.7574 mL 1.5149 mL 3.7872 mL
20 mM 0.1136 mL 0.5681 mL 1.1362 mL 2.8404 mL
25 mM 0.0909 mL 0.4545 mL 0.9089 mL 2.2723 mL
30 mM 0.0757 mL 0.3787 mL 0.7574 mL 1.8936 mL
40 mM 0.0568 mL 0.2840 mL 0.5681 mL 1.4202 mL
50 mM 0.0454 mL 0.2272 mL 0.4545 mL 1.1362 mL
60 mM 0.0379 mL 0.1894 mL 0.3787 mL 0.9468 mL
80 mM 0.0284 mL 0.1420 mL 0.2840 mL 0.7101 mL
100 mM 0.0227 mL 0.1136 mL 0.2272 mL 0.5681 mL
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6-Hydroxybenzbromarone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-Hydroxybenzbromarone152831-00-0Drug MetabolitePhosphataseMetabolitecellmigrationtubulogenesisanti-angiogenicbiotransformationInhibitorinhibitorinhibit

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